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Selected Publications
Martin KE, Hunckler MD, Chee E, Caplin JD, Barber GF, Kalelkar PP, Schneider RS, García AJ. Hydrolytic hydrogels tune mesenchymal stem cell persistence and immunomodulation for enhanced diabetic cutaneous wound healing. Biomaterials 301:122256 (2023). https://pubmed.ncbi.nlm.nih.gov/37517209/
Mora-Boza A, Mulero-Russe A, Caprio ND, Burdick JA, Singh A, García AJ. Facile photopatterning of perfusable microchannels in synthetic hydrogels to recreate microphysiological environments. Advanced Materials doi: 10.1002/adma.202306765 (2023). https://pubmed.ncbi.nlm.nih.gov/37775089/
Mora-Boza A, Ahmedin Z, García AJ. Controlled release of therapeutic antibody using hydrolytically degradable microgels. Journal of Biomedical Materials Research Part A doi: 10.1002/jbm.a.37637 (2023). https://pubmed.ncbi.nlm.nih.gov/37927169/
Coronel MM, Linderman SW, Martin KE, Hunckler MD, Medina JD, Barber G, Riley K, Yolcu ES, Shirwan H, García AJ. Delayed graft rejection in autoimmune islet transplantation via biomaterial immunotherapy. American Journal Transplantation 23: 1709-1722 (2023). https://pubmed.ncbi.nlm.nih.gov/37543091/
Colasurdo M, Nieves EB, Fernández-Yagüe MA, Franck C, García AJ. Adhesive peptide and polymer density modulate 3D cell traction forces within synthetic hydrogels. Biomaterials 288:121710 (2022). Link
Martin KE, Kalelkar PP, Coronel MM, Theriault HS, Schneider RS, García AJ. Host type 2 immune response to xenogeneic serum components impairs biomaterial-directed osteo-regenerative therapies. Biomaterials doi: 10.1016/j.biomaterials.2022.121601 (2022). Link
Lei J, Coronel MM, Yolcu ES, Deng H, Grimany-Nuno O, Hunckler MD, Ulker V, Yang Z, Lee KM, Zhang A, Luo H, Peters CW, Zou Z, Chen T, Wang Z, McCoy C, Rosales IA, Markmann JF#, Shirwan H#, García AJ#. FasL-microgels induce immune acceptance of islet allografts in nonhuman primates. Science Advances 8(19):eabm9881 (2022). Link
Hooks JST, Bernard FC, Cruz-Acuña R, Nepiyushchikh Z, Gonzalez-Vargas Y, García AJ, Dixon JB. Synthetic hydrogels engineered to promote collecting lymphatic vessel sprouting. Biomaterials 284:121483 (2022). Link
Fernandez-Yague MA, Hymel LA, Olingy CE, McClain C, Ogle ME, García JR, Minshew D, Vyshnya S, Lim HS, Qiu P, García AJ, Botchwey EA. Analyzing immune response to engineered hydrogels by hierarchical clustering of inflammatory cell subsets. Science Advances 8(8):eabd8056 (2022). Link
Schneider RS, Vela AC, Williams EK, Martin KE, Lam WA, García AJ. High-throughput on-chip human mesenchymal stromal cells potency prediction. Advanced Healthcare Materials 11(2):e2101995 (2022). Link
O'Melia MJ, Mulero-Russe A, Kim J, Pybus A, DeRyckere D, Wood L, Graham DK, Botchwey E, García AJ, Thomas SN. Synthetic matrix scaffolds engineer the in vivo tumor immune microenvironment for immunotherapy screening. Advanced Materials 34(10):e202108084 (2022). Link
Zhou DZ, Fernandez-Yague MA, Holland EN, García AF, Castro NS, O’Neill EB, Eyckmans JEG, Chen CS, Fu J, Schlaepfer DD, García AJ. Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair. Nature Communications 12(1):2359 (2021). Link
Kalelkar PP, Moustafa DA, Riddick M, Goldberg JB, McCarty NA, García AJ. Bacteriophage-loaded poly(lactic-co-glycolic acid) microparticles mitigate Staphylococcus aureus infection and cocultures of Staphylococcus aureus and Pseudomonas aeruginosa. Advanced Healthcare Materials 11(10):e2102539 (2021). Link
Coronel MM, Martin KE, Hunckler MD, Barber G, O'Neill EB, Medina JD, Opri E, McClain CA, Batra L, Weaver JD, Lim HS, Qiu P, Botchwey EA, Yolcu ES, Shirwan H, García AJ. Immunotherapy via PD-L1-presenting biomaterials leads to long-term islet graft survival.
Sci Adv. 2020 Aug 28;6(35):eaba5573. Link
Clark AY, Martin KE, García JR, Johnson CT, Theriault HS, Han WM, Zhou DW, Botchwey EA, García AJ. Integrin-specific hydrogels modulate transplanted human bone marrow-derived mesenchymal stem cell survival, engraftment, and reparative activities.
Nat Commun. 2020 Jan 8;11(1):114. Link
García JR, Quirós M, Han WM, O'Leary MN, Cox GN, Nusrat A, García AJ. IFN-γ-tethered hydrogels enhance mesenchymal stem cell-based immunomodulation and promote tissue repair.
Biomaterials. 2019 Nov;220:119403. Link
Han WM, Mohiuddin M, Anderson SE, García AJ, Jang YC. Co-delivery of Wnt7a and muscle stem cells using synthetic bioadhesive hydrogel enhances murine muscle regeneration and cell migration during engraftment.
Acta Biomater. 2019 Aug;94:243-252. Link
Johnson CT, Sok MCP, Martin KE, Kalelkar PP, Caplin JD, Botchwey EA, García AJ. Lysostaphin and BMP-2 co-delivery reduces S. aureus infection and regenerates critical-sized segmental bone defects.
Sci Adv. 2019 May 17;5(5):eaaw1228. Link
Hunckler MD, Medina JD, Coronel MM, Weaver JD, Stabler CL, García AJ. Linkage groups within thiol-ene photoclickable PEG hydrogels control in vivo stability.
Adv Healthc Mater. 2019 Jul;8(14):e1900371. Link
Agarwal R, Johnson CT, Imhoff BR, Donlan RM, McCarty NA, García AJ. Inhaled bacteriophage-loaded polymeric microparticles ameliorate acute lung infections. Nat Biomed Eng. 2018 Nov;2(11):841-849. link
Headen DM, Woodward KB, Coronel MM, Shrestha P, Weaver JD, Zhao H, Tan M, Hunckler MD, Bowen WS, Johnson CT, Shea L, Yolcu ES, García AJ, Shirwan H. Local immunomodulation with Fas ligand-engineered biomaterials achieves allogeneic islet graft acceptance. Nat Mater. 2018; 17(8):732-739. link
Johnson CT, Wroe JA, Agarwal R, Martin KE, Guldberg RE, Donlan RM, Westblade LF, García AJ. Hydrogel delivery of lysostaphin eliminates orthopedic implant infection by Staphylococcus aureus and supports fracture healing. Proc Natl Acad Sci USA. 2018; 115(22):E4960-E4969. link
Cruz-Acuña R, Quirós M, Huang S, Siuda D, Spence JR, Nusrat A, García AJ. PEG-4MAL hydrogels for human organoid generation, culture, and in vivo delivery. Nat Protoc. 2018 Sep;13(9):2102-2119. link
Erratum in: Nat Protoc. 2018 Oct 24.
Han WM, Anderson SE, Mohiuddin M, Barros D, Nakhai SA, Shin E, Amaral IF, Pêgo AP, García AJ, Jang YC. Synthetic matrix enhances transplanted satellite cell engraftment in dystrophic and aged skeletal muscle with comorbid trauma. Sci Adv. 2018 Aug 15;4(8):eaar4008. link
Cruz-Acuña R, Quirós M, Farkas AE, Dedhia PH, Huang S, Siuda D, García-Hernández V, Miller AJ, Spence JR, Nusrat A, García AJ. Synthetic hydrogels for human intestinal organoid generation and colonic wound repair. Nat Cell Biol. 2017; 19(11):1326-1335. link
Weaver JD, Headen DM, Aquart J, Johnson CT, Shea LD, Shirwan H, García AJ. Vasculogenic hydrogel enhances islet survival, engraftment, and function in leading extrahepatic sites. Sci Adv. 2017; 3(6):e1700184. link
Enemchukwu NO, Cruz-Acuña R, Bongiorno T, Johnson CT, García JR, Sulchek T, García AJ. Synthetic matrices reveal contributions of ECM biophysical and biochemical properties to epithelial morphogenesis. J Cell Biol. 2016; 212(1):113-24. link
Lee TT, García JR, Paez JI, Singh A, Phelps EA, Weis S, Shafiq Z, Shekaran A, del Campo A, García AJ. Light-triggered in vivo activation of adhesive peptides regulates cell adhesion, inflammation and vascularization of biomaterials. Nat Mater. 2015; 14(3):352-60. link
Shekaran A, García JR, Clark AY, Kavanaugh TE, Lin AS, Guldberg RE, García AJ. Bone regeneration using an alpha 2 beta 1 integrin-specific hydrogel as a BMP-2 delivery vehicle. Biomaterials. 2014; 35(21):5453-61. link
Headen DM, Aubry G, Lu H, García AJ. Microfluidic-based generation of size-controlled, biofunctionalized synthetic polymer microgels for cell encapsulation. Adv Mater. 2014; 26(19):3003-8. link
Dumbauld DW, Lee TT, Singh A, Scrimgeour J, Gersbach CA, Zamir EA, Fu J, Chen CS, Curtis JE, Craig SW, García AJ. How vinculin regulates force transmission. Proc Natl Acad Sci USA. 2013; 110:9788-93. link
Singh A, Suri S, Lee T, Chilton JM, Cooke MT, Chen W, Fu J, Stice SL, Lu H, McDevitt TC, García AJ. Adhesion strength-based, label-free isolation of human pluripotent stem cells. Nat Methods. 2013; 10(5):438-44. link
Coyer SR, Singh A, Dumbauld DW, Calderwood DA, Craig SW, Delamarche E, García AJ. Nanopatterning reveals an ECM area threshold for focal adhesion assembly and force transmission that is regulated by integrin activation and cytoskeleton tension. J Cell Sci. 2012; 125:5110-23. link
Phelps EA, Enemchukwu NO, Fiore VF, Sy JC, Murthy N, Sulchek TA, Barker TH, García AJ. Maleimide cross-linked bioactive PEG hydrogel exhibits improved reaction kinetics and cross-linking for cell encapsulation and in situ delivery. Adv Mater. 2012; 24(1):64-70. link
Petrie TA, Raynor JE, Dumbauld DW, Lee TT, Jagtap S, Templeman KL, Collard DM, García AJ. Multivalent integrin-specific ligands enhance tissue healing and biomaterial integration. Sci Transl Med. 2010; 2(45):45ra60. link
Phelps EA, Landázuri N, Thulé PM, Taylor WR, García AJ. Bioartificial matrices for therapeutic vascularization. Proc Natl Acad Sci USA. 2010; 107(8):3323-8. link
Phillips JE, Burns KL, Le Doux JM, Guldberg RE, García AJ. Engineering graded tissue interfaces. Proc Natl Acad Sci USA. 2008; 105(34):12170-5. link
Gersbach CA, Le Doux JM, Guldberg RE, García AJ. Inducible regulation of Runx2-stimulated osteogenesis. Gene Ther. 2006; 13(11):873-82. link
Gallant ND, Michael KE, García AJ. Cell adhesion strengthening: contributions of adhesive area, integrin binding, and focal adhesion assembly. Mol Biol Cell. 2005; 16(9):4329-40. link
Keselowsky BG, Collard DM, García AJ. Integrin binding specificity regulates biomaterial surface chemistry effects on cell differentiation. Proc Natl Acad Sci USA. 2005; 102(17):5953-7. link
Keselowsky BG, Collard DM, García AJ. Surface chemistry modulates fibronectin conformation and directs integrin binding and specificity to control cell adhesion. J Biomed Mater Res A. 2003; 66:247-59. link
Reyes CD, García AJ. Engineering integrin-specific surfaces with a triple-helical collagen-mimetic peptide. J Biomed Mater Res A. 2003; 65(4):511-23. link